کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5809827 1556174 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modeling the heterogeneous intestinal absorption of propiverine extended-release
ترجمه فارسی عنوان
مدل سازی جذب روده ای ناهمگونی پروپیوئین گسترش یافته است
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Propiverine is a widely used antimuscarinic drug with bioavailability that is limited by intestinal first-pass extraction. To study the apparent heterogeneity in intestinal first-pass extraction, we performed a population analysis of oral concentration-time data measured after administration of an extended-release formulation of propiverine in ten healthy subjects. Using an inverse Gaussian function as input model, the assumption that the systemically available fraction increases as a sigmoidal function of time considerably improved the fit. The step-like increase in this fraction at time t = 3.7 h predicted by the model suggests that propiverine is predominantly absorbed in colon. A nearly perfect correlation was found between the estimates of bioavailability and mean dissolution time.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 76, 30 August 2015, Pages 133-137
نویسندگان
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