کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5809923 | 1556185 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Polymer complex of WR 2721. Synthesis and radioprotective efficiency Polymer complex of WR 2721. Synthesis and radioprotective efficiency](/preview/png/5809923.png)
Polymer complex constructed from WR 2721 and poly(hydroxyoxyethylene phosphate) was synthesized. The structure of complex formed was elucidated by 1H-, 13C, 31P NMR and FT-IR spectroscopy. The radioprotector was immobilized via ionic bonds. Radioprotective efficacy was evaluated by clonal survival of stem cells in crypts of mouse small intestine, and incidence and latency of the acute radiation induced bone marrow syndrome. Protection factors were assessed for WR 2721 and for the polymer complex. Protection factors for the polymer complex ranged from 2.6 for intestinal stem cell survival to 1.35 for 30Â day survival (LD50) following whole body radiation exposure. In all cases, the polymer complex was a significantly better radiation protector than the parent compound.
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Journal: European Journal of Pharmaceutical Sciences - Volume 65, 18 December 2014, Pages 9-14