Relevance of equivalence assessment of topical products based on the dermatopharmacokinetics approach

This short review tries to describe and discuss some aspects under optimization of dermatopharmacokinetics as is the influence of the formulation on drug performance, the parameter calculation and the experimental procedure for minimizing variability. All those aspects are nowadays in continuous improvement trying to define the place of dermatopharmacokinetics as a putative technique for avoiding clinical trials in topical generics development.