کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5810280 | 1556262 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
A novel method has been developed to protect protein drugs in poly (lactic-co-glycolic acid) (PLGA) microspheres using S/O/O/W multi-emulsion method. This method develops a novel protein drug sustained-release system, which is based on the combination of protein-loaded dextran glassy microparticles (protein-loaded AqueSpheres) and PLGA microspheres. The protein molecules are encapsulated in the dextran glassy particles and the drug-containing dextran glassy particles are further dispersed in the PLGA microspheres. The protein-loaded AqueSpheres based PLGA composite microspheres have spherical shape and a smooth surface. They possess a normal size distribution and a mean diameter of 67.08 μm. The method may decrease protein aggregations and incomplete release due to avoiding protein contacting with oil/water interfaces and hydrophobic PLGA. The dextran glassy particles can stabilize proteins in the PLGA matrix, which is the major advantage of this novel protein sustained-release system over preparation for the PLGA microspheres using W/O/W double-emulsion method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 36, Issues 2â3, 15 February 2009, Pages 212-218
Journal: European Journal of Pharmaceutical Sciences - Volume 36, Issues 2â3, 15 February 2009, Pages 212-218
نویسندگان
Weien Yuan, Fei Wu, Meiyan Guo, Tuo Jin,