کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5810486 1556554 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential efficiency of antioxidants to prevent pressure ulcers. A neglected hypothesis
ترجمه فارسی عنوان
راندمان بالقوه آنتی اکسیدان ها برای جلوگیری از زخم های فشار. فرضیه غفلت شده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Pressure ulcers are necrotic lesions mainly due to capillary hypoperfusion. It is well known that hypoxia and also subsequent oxygenation at reperfusion provoke the formation of reactive oxygen species (ROS) responsible for cell death. The hypothesis of their participation in the pathogenesis of pressure ulcers has already been tested; several antioxidants have the capacity to inhibit skin necrosis in animal models but their efficiency in preventing bedsores has never been demonstrated in patients. The failure of clinical trials to show the protective activity of some antioxidants does not rule out the involvement of ROS in ischemic ulcers and the potential efficacy of other antioxidants in preventing their formation remains possible.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 91, June 2016, Pages 28-31
نویسندگان
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