کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5811547 1115013 2014 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Should we be more cautious about replacement of vitamin B12 in patients with cancer receiving cytotoxic chemotherapy?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Should we be more cautious about replacement of vitamin B12 in patients with cancer receiving cytotoxic chemotherapy?
چکیده انگلیسی
Vitamin B12 (Cbl) deficiency may cause hematologic and neurologic dysfunction. Replacement therapy is effective in correcting hematologic abnormalities and improving neurologic symptoms. Cbl is known to have antioxidant activity. This antioxidant activity may antagonize the effects of chemotherapeutics (i.e. genotoxic effects of paclitaxel) on tumor DNA. We claim that Cbl replacement should be done more cautiously in patients receiving cytotoxic chemotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 83, Issue 6, December 2014, Pages 726-729
نویسندگان
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