کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5812136 1115029 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathological niche environment transforms dermal stem cells to keloid stem cells: A hypothesis of keloid formation and development
ترجمه فارسی عنوان
محیط زیست آسیب شناسی سلول های بنیادی پوستی را به سلول های بنیادی کلئوئیدی تبدیل می کند: یک فرضیه از تشکیل و توسعه کلوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Keloid is a disease that is difficult to cure because of its high recurrence rate after chemotherapy or radiotherapy, therefore it is considered as a benign skin tumor. Tumor stem cells are proposed as the source for tumor development and post-therapy recurrence. Interestingly, keloid stem cells have also been discovered, which share some characters with those of skin progenitor cells. Keloid patients possess specific diathesis including genetic predisposition and gene mutation, abnormal levels of hormones, growth factors and cytokines, and strong inflammatory response. This article reviews related literatures and hypothesizes that keloid stem cells might be transformed from normal dermal progenitor cells in the pathological niche of keloid tissues. These keloid stem cells are highly self-renewal and drug resistant, and can sustain themselves by asymmetric division, and continually generate new keloid cells to replenish the cells killed by drugs or radiation, thus leading to over growth of keloid and high post-therapy recurrence rate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 81, Issue 5, November 2013, Pages 807-812
نویسندگان
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