کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5812148 1115029 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vascular damage: A persisting pathology common to Alzheimer's disease and traumatic brain injury
ترجمه فارسی عنوان
خسارت عروقی: یک پاتولوژی پایدار مشترک با بیماری آلزایمر و آسیب مغزی آسیب دیده است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
Alzheimer's disease (AD) and traumatic brain injury (TBI) are both significant clinical problems characterized by debilitating symptoms with limited available treatments. Interestingly, both neurological diseases are characterized by neurovascular damage. This impaired brain vasculature correlates with the onset of dementia, a symptom associated with hippocampal degeneration seen in both diseases. We posit that vascular damage is a major pathological link between TBI and AD, in that TBI victims are predisposed to AD symptoms due to altered brain vasculature; vice versa, the progression of AD pathology may be accelerated by TBI especially when the brain insult worsens hippocampal degeneration. Our hypothesis is supported by recent data reporting expedited AD pathology in presymptomatic transgenic AD mice subjected to TBI. If our hypothesis is correct, treatments targeted at repairing the vasculature may prove effective at treating both diseases and preventing the evolution of AD symptoms in TBI victims.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 81, Issue 5, November 2013, Pages 842-845
نویسندگان
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