کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5812245 1115030 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Possible carcinogenesis of tumor suppressor let-7
ترجمه فارسی عنوان
سرطان زایی ممکن از سرکوبگر تومور اجازه دهید 7
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Cancer stem cells (CSCs), a group showing high capacities of sphere-forming and self renewal, are blamed for tumor initiation, recurrence and therapy resistance. Therefore, therapeutics specifically targeting and perishing CSCs may be promising. Let-7 miRNAs, one of the earliest discovered miRNAs, were considered as novel and vital agents to eliminate cancer and CSCs. However, in recent researches, many regulatory loops among let-7 and its targeted genes were noticed; the regulation of let-7 caused by its hunting mRNAs helped to form the hypotheses that hunters and preys may swap their roles when in confrontations. Besides, the evil side of let-7 was discovered occasionally, therefore, we hypothesize that dual characteristics of let-7 do exist, which will have significant impacts on anticancer research. Targeted therapies against cancer and CSCs by using let-7 or other miRNAs as weapons should be thought twice before clinical application.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 81, Issue 3, September 2013, Pages 410-413
نویسندگان
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