کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5814 437 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced dual contrast agent, Co2+-doped NaYF4:Yb3+,Tm3+ nanorods, for near infrared-to-near infrared upconversion luminescence and magnetic resonance imaging
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Enhanced dual contrast agent, Co2+-doped NaYF4:Yb3+,Tm3+ nanorods, for near infrared-to-near infrared upconversion luminescence and magnetic resonance imaging
چکیده انگلیسی

Dual-modality imaging with magnetic resonance (MR) and upconversion luminescence (UCL) is a promising technique for molecular imaging in biomedical research. Multifunctional lanthanide-based nanoparticles have been widely investigated as agents for contrast enhanced MR and fluorescence imaging. However, the use of rare earth fluoride nanoparticles for dual-modality imaging of T2-weighted MR and UCL is rarely reported. We find that NaYF4:Yb3+,Tm3+,Co2+ (MUC) nanorods can be applied as a high-performance dual contrast agent for both T2-weighted MR and UCL dual-modality imaging. After modification with 6-O-carboxymethyl chitosan (OCC), MUC nanorods can be endocytosed by cells without showing signs of cytotoxicity. High-quality UCL images of living cells incubated with MUC-OCC nanorods were acquired on a near-infrared (NIR) confocal microscopy under the excitation at 980 nm. Moreover, MUC-OCC nanorods display high transverse (r2) relaxivities in vitro. The application of low-dose MUC-OCC nanorods for NIR-to-NIR UCL and MR dual-modality in vivo imaging was also carried out successfully. In addition, the toxicity of MUC-OCC nanorods was evaluated by MTT assay, serological tests and histological analysis of visceral organs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 35, Issue 33, November 2014, Pages 9167–9176
نویسندگان
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