کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5816568 1116146 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Limonene inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal function and dopamine release
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Limonene inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal function and dopamine release
چکیده انگلیسی
Methamphetamine is a psychomotor stimulant that produces hyperlocomotion in rodents. Limonene (a cyclic terpene from citrus essential oils) has been reported to induce sedative effects. In this study, we demonstrated that limonene administration significantly inhibited serotonin (5-hydroxytryptamine, 5-HT)-induced head twitch response in mice. In rats, pretreatment with limonene decreased hyperlocomotion induced by methamphetamine injection. In addition, limonene reversed the increase in dopamine levels in the nucleus accumbens of rats given methamphetamine. These results suggest that limonene may inhibit stimulant-induced behavioral changes via regulating dopamine levels and 5-HT receptor function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 21, Issue 6, 15 May 2014, Pages 883-887
نویسندگان
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