کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5816764 1116160 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationIntramuscular and topical treatment of cutaneous leishmaniasis lesions in mice infected with Leishmania amazonensis using coumarin (−) mammea A/BB
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Short communicationIntramuscular and topical treatment of cutaneous leishmaniasis lesions in mice infected with Leishmania amazonensis using coumarin (−) mammea A/BB
چکیده انگلیسی

Treatment of cutaneous leishmaniasis remains limited to a few available options. Recent studies showed in vitro antileishmanial activity of (−) mammea A/BB, a coumarin isolated from leaves of Calophyllum brasiliense. Moreover, the dichloromethane crude extract and hexane fraction from this plant demonstrated in vivo activity in mice infected with Leishmania amazonensis. We evaluated the antileishmanial activity of (−) mammea A/BB in the L. amazonensis BALB/c mice model. The animals were given intramuscular and topical treatment with (−) mammea A/BB for 30 consecutive days. The results demonstrated that 18 mg/kg/d intramuscularly or 0.2% topically of (−) mammea A/BB significantly reduced the size of skin lesions in footpads of mice compared with those in the control group (p < 0.05). The activity of Glucantime® (corresponding to 27 mg/kg/d of pentavalent antimony) administered intramuscularly was similar to that of (−) mammea A/BB (p < 0.05) by both routes of administration. The histopathological evaluation showed no changes in the organs analyzed. These results indicate that the coumarin obtained from C. brasiliense is the antileishmanially active compound and can be used to control the development of cutaneous leishmaniasis lesions caused by L. amazonensis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 19, Issue 13, 15 October 2012, Pages 1196-1199
نویسندگان
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