کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5816998 | 1556704 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
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کلمات کلیدی
PBSDABNODTNFIgGSjogren's syndrome (SS)pKaMMP-93,3′-diaminobenzidine - 3،3'-diaminobenzidineMAPK - MAPKDendrobium candidum - ارکیده دندروبیوم سفیدimmunoglobulin G - ایمونوگلوبولین Ginterleukin - اینترلوکینNon-obese diabetic - دیابتی غیر چاقیSjögren's syndrome - سندرم SjögrenLabial gland - غدد لنفاویtumor necrosis factor - فاکتور نکروز تومورphosphate buffer saline - فسفات بافر شورMatrix metalloproteinase-9 - ماتریکس متالوپروتئیناز -9Mechanisms - مکانیسم هاNitric oxide - نیتریک اکسیدHelicobacter pylori - هلیکوباکتر پیلوریprotein kinase A - پروتئین کیناز Amitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome](/preview/png/5816998.png)
چکیده انگلیسی
This study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 18, Issues 2â3, 15 January 2011, Pages 194-198
Journal: Phytomedicine - Volume 18, Issues 2â3, 15 January 2011, Pages 194-198
نویسندگان
Lin Xiao, Tzi Bun Ng, Yi-Bin Feng, Tong Yao, Jack Ho Wong, Ren-Min Yao, Lei Li, Fei-Zhi Mo, Yin Xiao, Pang-Chui Shaw, Ze-Min Li, Stephen Cho Wing Sze, Kalin Yanbo Zhang,