Pulmonary, gastrointestinal and urogenital pharmacologyRole of selective blocking of bradykinin receptor subtypes in attenuating allergic airway inflammation in guinea pigs

- Role of bradykinin B1 receptors in allergic inflammation is supported by the results of this research.
- Selective blocking of bradykinin B1 receptors by R-715 suppressed allergic airway inflammation in guinea pigs.
- The importance of bradykinin B2 receptors in sharing of allergic inflammation is degraded herein.

The present study was designed to evaluate the potential role of bradykinin antagonists (R-715; bradykinin B1 receptor antagonist and icatibant; bradykinin B2 receptor antagonist) in treatment of allergic airway inflammation in comparison to dexamethasone and montelukast. R-715 as dexamethasone significantly decreased peribronchial leukocyte infiltration, bronchoalveolar lavage fluid (BALF) albumin and interleukin 1β as well as serum OVA-specific IgE level. Also, R-715 like montelukast significantly decreased BALF cell count (total and eosinophils). Icatibant showed negative results. The current findings suggest that selective bradykinin B1 receptor antagonists may have the therapeutic potential for the treatment of allergic airway inflammation.