کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5826951 | 1558915 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The hypotensive effect of the nitric monoxide donor Oxacom at different routs of its administration to experimental animals
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کلمات کلیدی
SDSS-nitrosoglutathioneBSA - BSAHypotension - افت فشارخونintraperitoneal - داخل صفاقیIntravenous - داخل وریدیRectal - رکتومsubcutaneous - زیر جلدیsodium dodecyl sulfate - سدیم دودسیل سولفاتIntramuscular - عضلانیmean arterial pressure - فشار متوسط شریانیDinitrosyl iron complexes - مجتمع آهن دینیتروسیلmap - نقشه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Earlier it has been found that the hypotensive drug Oxacom containing binuclear dinitrosyl iron complexes (B-DNIC) with glutathione can effectively decrease, as a nitric monooxide (NO) donor, the mean arterial pressure (ÐÐÐ ) in rats upon intravenous bolus injection in the form of an aqueous solution (Chazov et al., 2012). The aim of this study was to investigate the hypotensive effects of Oxacom administered to experimental rats by intravenous, intramuscular, subcutaneous, intraperitoneal, intragastric, rectal routes.MAP and heart rate (HR) were measured with the help of arterial catheters equipped with tensometric sensors. Oxacom was administered to rats at the dose of 2.0 μmole of B-DNIC/kg. The concentration of paramagnetic mononuclear protein-bound DNIC (Ð-DNIC) formed in the blood and tissues of various internal organs of the rat was determined by the EPR method. Upon subcutaneous, intramuscular or intraperitoneal administration of Oxacom, the maximum amplitude of the ÐÐÐ decrease varies from 30% to 70%, respectively, in comparison with the corresponding parameter for the intravenously injected Oxacom. Another difference is the lack of the fast phase in the initial stage of the ÐÐÐ decrease and the longer persistence of protein-bound M-DNIC formed in the circulating blood after intramuscular, subcutaneous or intraperitoneal administration of Oxacom. Thus, the NO donor Oxacom exerts pronounced hypotensive effects on rats not only upon intravenous, but also upon intramuscular, subcutaneous or intraperitoneal administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 765, 15 October 2015, Pages 525-532
Journal: European Journal of Pharmacology - Volume 765, 15 October 2015, Pages 525-532
نویسندگان
Alexander Ð. Тimoshin, Vladimir L. Lakomkin, Alexander Ð. Ðbramov, Enno K. Ruuge, Valery I. Kapel'ko, Evgeny I. Chazov, Anatoly F. Vanin,