کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5827592 | 1558938 | 2014 | 5 صفحه PDF | دانلود رایگان |
Both NMDA receptor and kynurenic acid (KYNA), a glycine-site NMDA receptor antagonist, are present in the kidney yet their functional role remains unclear. Our aim was to examine effects of intravenous KYNA and glycine on arterial blood pressure (MAP) and renal haemodynamics and excretion in anaesthetized normotensive Sprague-Dawley (S-D) and in spontaneously hypertensive (SHR) rats. Renal blood flow (RBF, renal artery probe) and renal cortical (CBF) and outer- and inner medullary perfusion (laser-Doppler) were measured, along with diuresis (V) and sodium excretion (UNaV). KYNA given alone (150 mg kgâ1 iv) or during infusion of glycine at 1 g kgâ1 hâ1 iv (G+K) increased or decreased RBF, respectively, in both S-D and SHR. Neither treatment altered MAP. In both strains glycine alone increased RBF and CBF 50-60% and was clearly diuretic and natriuretic, less so in SHR. KYNA increased UNaV by 4.1±1.7 μmol minâ1and V by 11.1±4.3 μl minâ1 in S-D (P<0.05 for both); the respective increases in SHR were by 1.7±0.6 μmol minâ1 and 4.7±1.7 μl minâ1 (P<0.02 for both). G+K treatment increased UNaV by 5.2±1.4 μmol minâ1 (P<0.01) and V by 29.6±4.6 μmol minâ1 (P<0.001) in S-D, and by 2.7±0.7 μmol minâ1 (P<0.05) and 19.3±3.5 μl minâ1 (P<0.0006) in SHR. In conclusion, KYNA increased renal excretion, apparently by inhibiting tubular reabsorption, whereas glycine substantially increased renal haemodynamics by an ill-defined mechanism, with a secondary increase in the excretion. Combined G+K treatment could be utilised to combat body fluid retention and possibly alleviate hypertension, without endangering renal perfusion and function.
Journal: European Journal of Pharmacology - Volume 743, 15 November 2014, Pages 37-41