کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5827790 1558934 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewIs there evidence for recommending specific intravenous immunoglobulin formulations? A systematic review of head-to-head randomized controlled trials
ترجمه فارسی عنوان
آیا شواهد موجود برای توصیف فرمولاسیون های ایمونوگلوبولین خاص داخل وریدی وجود دارد؟ بررسی سیستماتیک آزمایشات کنترل شده تصادفی سر به سر
کلمات کلیدی
ایمونوگلوبولین داخل وریدی، آزمایشات کنترل شده تصادفی سرم به سر، اثر، بررسی سیستماتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

Intravenous immunoglobulins (IVIG) have been used for several licensed and off-label indications. Each IVIG product is a unique formulation of IgG and excipients, making them distinct products. How these differences impact on individual IVIG product efficacy and safety are not well established but can be investigated by head-to-head randomized controlled trials (RCT). A systematic review of head-to-head RCT comparing different formulations of IVIG, regardless of the target condition and outcomes investigated. Two reviewers screened 4084 citations retrieved from MEDLINE, Embase, Cochrane and LILACS, and 23 citations were fully-text evaluated. Eight trials were included. The clinical conditions, outcomes and risk of bias were assessed. Of the eight trials included only two investigated products that are currently on the market. One evaluated two Grifols brands used in patients with primary immunodeficiency and another evaluated two Baxter brands used in patients with chronic inflammatory demyelinating polyradiculoneuropathy. There were no differences between the formulations for the outcomes evaluated. In the other trials, either the manufacturers were acquired by other companies or the formulation was withdrawn from the market. As consequence, evidence concerning these products could not be considered. The quality of the studies was low, showing high risk of bias. Direct evidence about the different IVIGs is scarce and, at present, there is no scientific evidence that can be applied for a specific brand or formulation. Further comparative effectiveness studies are highly desirable for a better understanding of the differences in safety and efficacy of IVIGs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 747, 15 January 2015, Pages 96-104
نویسندگان
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