کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5827948 | 1558943 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nalmefene reverses carfentanil-induced loss of righting reflex and respiratory depression in rats
ترجمه فارسی عنوان
نالمفن از دست دادن پارگی رفلکس و تنفس در موش صحرائی ناشی از کارفنتانیل
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Reversing the respiratory depression induced by carfentanil involves intravenous administration of naloxone or naltrexone, but this treatment has disadvantages. Hence, finding a more appropriate treatment to counter the depressive actions of carfentanil is needed. In the present study, with the naloxone as a control, we investigated the efficacy of nalmefene for countering the depressive actions of carfentanil. Rats were treated successively with carfentanil (10 μg/kg, i.v.) and nalmefene (9.4-150.0 μg/kg, i.m.), and the duration of loss of righting reflex (LORR) recorded. Respiratory parameters were measured in free-moving rats using a whole-body plethysmograph after rats were administered carfentanil (20 μg/kg, i.v.) and nalmefene (9.4-150.0 μg/kg, i.m.) sequentially. The parameters of arterial blood gases were also examined. Nalmefene (9.4-150.0 μg/kg, i.m.) treatment dose-dependently decreased the duration of carfentanil-induced LORR. The respiratory rate after 60 min of nalmefene (150.0 μg/kg, i.m.) treatment increased from 34.3±5.3 bursts/min to 117.8±18.9 bursts/min, and enhanced pause decreased from 1.1±0.1 to 0.4±0.1, and was close to those of normal rats. Furthermore, nalmefene (37.5-150.0 μg/kg) treatment could enable the PaO2, SaO2 and PaCO2 to approach normal levels 10 min (15 min after carfentanil injection) or 30 min (25 min after carfentanil injection) after injection. While, a single injection of naloxone (150.0 μg/kg, i.m.) only achieved partial remission of respiratory depression. These data suggest that nalmefene more effectively counters the depressive actions induced by carfentanil and is a more appropriate treatment to antagonize carfentanil toxicity compared with naloxone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 738, 5 September 2014, Pages 153-157
Journal: European Journal of Pharmacology - Volume 738, 5 September 2014, Pages 153-157
نویسندگان
Zheng Yong, Xiang Gao, Wentao Ma, Huajing Dong, Zehui Gong, Ruibin Su,