کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828058 | 1558951 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spermidine improves fear memory persistence
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Persistence is the most characteristic attribute of long-term memory (LTM). For memory persistence, a second late event of consolidation, that occurs around 12Â h after the acquisition, is necessary. Although the N-methyl-d-aspartate (NMDA) receptor has been involved in the persistence of memory, whether endogenous modulators of the NMDA receptor actually modulate memory persistence is unknown. In the current study we investigated whether spermidine and arcaine, respectively agonist and antagonist of polyamine binding site at NMDA receptor, alter the persistence of the memory of contextual fear conditioning task in rats. While 12Â h post-training administration of spermidine (10 and 30Â mg/kg, i.p.) facilitated, arcaine (10Â mg/kg, i.p.) impaired the memory of fear assessed 2 and 7 days after training. Arcaine (0.1Â mg/kg) prevented the facilitatory effect of spermidine (10Â mg/kg, i.p.), and spermidine (1Â mg/kg), prevented the memory impairment induced by arcaine (10Â mg/kg, i.p.) when tested 2 and 7 days after training. These results suggest that endogenous polyamines improve the persistence of fear memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 730, 5 May 2014, Pages 72-76
Journal: European Journal of Pharmacology - Volume 730, 5 May 2014, Pages 72-76
نویسندگان
Cristiane Signor, Carlos F. Mello, Gerusa P. Porto, Daniela A. Ribeiro, Maribel A. Rubin,