کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828060 | 1558951 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats
ترجمه فارسی عنوان
مکانیسم کاهش آنزیم های مهار کننده آنزیم آنژیوتانسین در موش های حاد بالینی
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کلمات کلیدی
Angiotensin II type 1 receptor blocker - آنژیوتانسین II نوع 1 گیرنده گیرندهAngiotensin converting enzyme inhibitor - آنژیوتانسین تبدیل آنزیم مهار کنندهEnalaprilat - انالاپریلاتtumor necrosis factor-alpha - تومور نکروز عامل آلفاIntraocular pressure - فشار داخل چشمmatrix metalloproteinase - ماتریکس متالوپروتئیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Angiotensin converting enzyme inhibitors (ACEIs) have been shown to lower intraocular pressure (IOP). Since, the ACEIs cause increased tissue prostaglandin levels, we hypothesized that the mechanisms of ACEI-induced IOP reduction have similarity with those of prostaglandin analogs. The present study investigated the involvement of matrix metalloproteinases (MMPs) and cytokine activity modulation as the underlying mechanisms of ACEI-induced ocular hypotension. The IOP lowering effect of single drop of enalaprilat dehydrate 1% was evaluated in rats pretreated with a broad spectrum MMP inhibitor or a cytokine inhibitor. Effect of angiotensin receptor blocker, losartan potassium 2%, was also studied to evaluate involvement of angiotensin II receptor type 1 (AT1) in IOP lowering effect of ACEI. Topical treatment with single drop of enalaprilat resulted in significant IOP reduction in treated eye with mean peak reduction 20.3% at 3Â h post-instillation. Treatment with losartan resulted in a peak IOP reduction of 13.3%, which was significantly lower than enalaprilat, indicating involvement of mechanisms in addition to AT1 blockade. Pretreatment with a broad spectrum MMP inhibitor or a cytokine inhibitor significantly attenuated the enalprilat-induced IOP reduction with mean peak IOP reduction of 11.2% and 13.6% respectively. The IOP-lowering effect of enalaprilat seems to be attributed to reduced angiotensin II type 1 receptor stimulation and modulation of MMP and cytokines activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 730, 5 May 2014, Pages 8-13
Journal: European Journal of Pharmacology - Volume 730, 5 May 2014, Pages 8-13
نویسندگان
Renu Agarwal, Anna V. Krasilnikova, Raja Intan Safinaz, Puneet Agarwal, Nafeeza Mohd Ismail,