کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828177 | 1558960 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydrogen peroxide modulates phenylephrine-induced contractile response in renal hypertensive rat aorta
ترجمه فارسی عنوان
پراکسید هیدروژن واکنش انقباضی ناشی از فنیل افرین را در بیماران مبتلا به آئورت رتین پرفشاری خون مدول می کند
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Endothelium-derived factors play an important role in vascular tone control. This study aimed to evaluate how endothelium and reactive oxygen species (ROS) contribute to phenylephrine (PE)-induced contraction in renovascular hypertensive (2K-1C) and normotensive (2K) rats aortas. The effects of the superoxide scavenger Tiron (0.1Â mM and 1Â mM) or catalase (30Â U/ml, 90Â U/ml, 150Â U/ml and 300Â U/ml) on the PE-induced contraction were evaluated in both intact endothelium (E+) and denuded (Eâ) aortas. Endothelium removal increased the PE-induced contractions. The maximum contractile response decreased only in 2K-1C rat E+ aorta, and catalase (30Â U/ml, 90Â U/ml, 150Â U/ml) partially reversed this effect. Endothelium increased the basal hydrogen peroxide (H2O2) production in 2K and 2K-1C rats aortas. PE-stimulated H2O2 production was higher in 2K-1C (E+/Eâ) than in 2K (E+/Eâ). Inhibition of the enzymes cyclooxygenase, NADPH-oxidase, xanthine-oxidase, and superoxide dismutase reduced the PE-stimulated H2O2 production in 2K-1C rat aorta. The decreased contraction to PE in 2K-1C rat aorta is partially due to endothelial H2O2 production; however, in denuded aorta, it contributes to maintaining the contractile response. Superoxide plays an important role on the PE-induced contraction in 2K rat denuded aorta, whereas in 2K-1C rat aorta, it is H2O2 that plays an important role in this effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 721, Issues 1â3, 5 December 2013, Pages 193-200
Journal: European Journal of Pharmacology - Volume 721, Issues 1â3, 5 December 2013, Pages 193-200
نویسندگان
Bruno R. Silva, Laena Pernomian, Marcella D. Grando, Jefferson H. Amaral, José E. Tanus-Santos, Lusiane M. Bendhack,