کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5828265 | 1558965 | 2013 | 16 صفحه PDF | دانلود رایگان |
Sigma 1 receptor (Ï1 receptor) is a unique ligand-regulated molecular chaperone located mainly in the endoplasmic reticulum and the plasma membrane. Ï1 receptor is activated under stress or pathological conditions and interacts with several neurotransmitter receptors and ion channels to modulate their function. The effects reported preclinically with Ï1 receptor ligands are consistent with a role for Ï1 receptor in central sensitization and pain hypersensitivity and suggest a potential therapeutic use of Ï1 receptor antagonists for the management of neuropathic pain as monotherapy. Moreover, data support their use in opioid adjuvant therapy: combination of Ï1 receptor antagonists and opioids results in potentiation of opioid analgesia, without significant increases in opioid-related unwanted effects. Results from clinical trials using selective Ï1 receptor antagonists in several pain conditions are eagerly awaited to ascertain the potential of Ï1 receptor modulation in pain therapy.
Journal: European Journal of Pharmacology - Volume 716, Issues 1â3, 15 September 2013, Pages 78-93