کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5829063 | 1558982 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular and cellular pharmacologyPDGF α receptor is a mediator for Cisplatin-induced Met expression
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular and cellular pharmacologyPDGF α receptor is a mediator for Cisplatin-induced Met expression Molecular and cellular pharmacologyPDGF α receptor is a mediator for Cisplatin-induced Met expression](/preview/png/5829063.png)
چکیده انگلیسی
For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor α receptor (PDGF α receptor)-mediated signaling plays a key role in hepatocyte growth factor (HGF) receptor (c-Met) upregulation, which in turn is thought to play an important role in chemotherapy resistance. PDGF α receptor inhibition eliminates cisplatin-dependent Met expression in cervical cancer cell lines. PDGF α receptor inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering of people from drug resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 699, Issues 1â3, 15 January 2013, Pages 227-232
Journal: European Journal of Pharmacology - Volume 699, Issues 1â3, 15 January 2013, Pages 227-232
نویسندگان
Shinichiro Kina, Thongsavanh Phonaphonh, Feixin Liang, Hai Kuang, Akira Arasaki, Keiichi Arakaki, Toshiyuki Nakasone, Hajime Sunakawa,