کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5829439 | 1558992 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inflammatory milieu as an early marker of kidney injury in offspring rats from diabetic mothers
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
The present study investigated the early presence of inflammatory response in renal tissue of young offspring from diabetic mothers. The effect of l-arginine (l-arg) supplementation was also investigated. The offspring was divided into four groups: group CO (controls); group DO (diabetic offspring); group CA (CO receiving 2% l-arg solution) and group DA (DO receiving the 2% l-arg solution). Glycemia, arterial pressure and renal function were evaluated; gene and protein expression of pro-inflammatory cytokines were also measured. Blood pressure levels were significantly increased in 2 and 6 month-old DO rats, whereas l-arg administration caused a significant decrease in the DA group, at both ages. DO rats showed a significantly blunted glycemic response to exogenous insulin. In 2 month-old DO animals, renal protein expression of pro-inflammatory molecules was significantly increased. At six months of age, we also observed an increase in gene expression of pro-inflammatory molecules, whereas l-arg supplementation prevented this increase at both ages. Our data suggest that activation of inflammatory pathways is present early in the kidney of DO rats, and that l-arg can attenuate the expression of these markers of tissue inflammation. Our results also reinforce the concept that intrauterine environmental factors are a fundamental determinant in the development of metabolic and vascular diseases later in life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 689, Issues 1â3, 15 August 2012, Pages 233-240
Journal: European Journal of Pharmacology - Volume 689, Issues 1â3, 15 August 2012, Pages 233-240
نویسندگان
Matheus Correa-Costa, Maristella A. Landgraf, Maria F. Cavanal, Patricia Semedo, Daniel A.G. Vieira, Davi T.K. De Marco, Aparecida E. Hirata, Niels O.S. Câmara, Frida Z. Gil,