کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5829530 | 1558996 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Idesolide inhibits the adipogenic differentiation of mesenchymal cells through the suppression of nitric oxide production
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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![عکس صفحه اول مقاله: Idesolide inhibits the adipogenic differentiation of mesenchymal cells through the suppression of nitric oxide production Idesolide inhibits the adipogenic differentiation of mesenchymal cells through the suppression of nitric oxide production](/preview/png/5829530.png)
چکیده انگلیسی
Obesity is a major health problem worldwide and can increase the risk for several chronic diseases, including diabetes and cardiovascular disease. In this study, we screened small compounds isolated from natural products for the development of an anti-obesity drug. Among them, idesolide, a spiro compound isolated from the fruits of Idesia polycarpa Maxim, showed a significant suppression of the adipogenic differentiation in mesenchymal cells, as indicated by the decrease in fat droplets and expression of adipogenic marker genes such as aP2 and adiponectin. Idesolide inhibits the PPARγ-mediated gene transcription in a dose-dependent manner, revealed by luciferase reporter gene assay. During adipogenic differentiation, idesolide inhibits nitric oxide production through the suppression of iNOS expression, and the increased adipogenic differentiation by arginine, the substrate for NOS, is significantly inhibited by idesolide, suggesting that the inhibition of nitric oxide production plays a major role in idesolide-induced adipogenic suppression. Taken together, the results reveal that idesolide has anti-adipogenic activity and highlight its potential in the prevention and treatment of obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 685, Issues 1â3, 15 June 2012, Pages 218-223
Journal: European Journal of Pharmacology - Volume 685, Issues 1â3, 15 June 2012, Pages 218-223
نویسندگان
Jun-Ha Hwang, Sung Ah Moon, Cham Han Lee, Mi Ran Byun, A Rum Kim, Mi Kyung Sung, Hyun-Jin Park, Eun Sook Hwang, Sang Hyun Sung, Jeong-Ho Hong,