کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5830133 | 1559014 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel electropharmacological activity of amiodarone on human HCN channels heterologously expressed in the Xenopus oocytes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel electropharmacological activity of amiodarone on human HCN channels heterologously expressed in the Xenopus oocytes Novel electropharmacological activity of amiodarone on human HCN channels heterologously expressed in the Xenopus oocytes](/preview/png/5830133.png)
چکیده انگلیسی
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the pacemaker currents (If) in cardiac cells. The objectives of this study were to investigate the electropharmacological activity of amiodarone on human HCN channels heterologously expressed in Xenopus laevis oocytes. hHCN channels were expressed in oocytes and studied using the standard two-electrode voltage-clamp techniques. The results show that amiodarone blocks hHCN channels heterologously expressed in the Xenopus oocytes in a concentration- and use-dependent manner, but doesn't modify the voltage dependence of activation and reversal potentials. And the removal of blockage of HCN channels by amiodarone was favored by inward current flow, not by hyperpolarizing potential. Characteristics of blockage on hHCN channels were consistent with those of amiodarone as “trapped” drugs on human ether-a-go-go-related gene (HERG) channels. These results will be useful for elucidating the potentially antiarrhythmic mechanism of amiodarone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 669, Issues 1â3, 1 November 2011, Pages 15-23
Journal: European Journal of Pharmacology - Volume 669, Issues 1â3, 1 November 2011, Pages 15-23
نویسندگان
Xinrong Fan, Yongjun Chen, Pan Wu, Junlian Xing, Hui Chen, Tao Song, Jing Yang, Jun Zhang, Congxin Huang,