Triterpenoids with anti-tobacco mosaic virus activities from Melia Toosendan

Four new triterpenoids, named Toosendansins A-D (1-4) along with nine known ones (5-13), were isolated from the fruits of Melia toosendan Sieb. et Zucc, and compounds 1-3 belong to nimbin-type limonoids. The isolation of compounds 1-12 were reported for the first time from this plant. All compounds were analyzed for the anti-Tobacco Mosaic Virus (TMV) activity and protective effect on H2O2-induced damage of SH-SY5Y cells.173