Glomexanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour

Three novel xanthonolignoid C-glycosides, glomexanthones A-C, with a trans-dihydrobenzofuran on B ring and a 2-hydroxymethyl-5-hydroxyl-2-pentenoic acid moiety in the sugar chain were isolated from an ethanol extract of Polygala glomerata. Their structures and absolute configurations were characterized by extensive NMR, MS, and CD spectroscopic studies. Screening results indicated that compounds 1-3 showed moderate neuroprotective effects on l-Glutamic acid-induced cellular damage in human neuroblastoma SK-N-SH cells.

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