The 1,4-naphthoquinone derivative from Pyrola rotundifolia activates AMPK phosphorylation in C2C12 myotubes

A novel AMPK activator from Pyrola rotundifolia L. was identified as a 2-methyl-7-hydroxymethyl-1,4-naphthoquinone or a 7′-hydroxy-chimaphilin.33