کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849416 | 1561753 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A dietary two-generation reproductive toxicity study of (2R,4R)-monatin salt in Crl:CD(SD) rats
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کلمات کلیدی
FDAPNDOECDmetestrusAAALACNOAELGLPBSA - BSAbovine serum albumin - آلبومین سرم گاوUS Food and Drug Administration - اداره غذا و داروی ایالات متحدهGood Laboratory Practice - تمرین خوب آزمایشگاهیdiestrus - دئیستروسOral - دهانیgestation day - روز بارداریlactation day - روز شیردهیpostnatal day - روز پس از زایمانOrganisation for Economic Cooperation and Development - سازمان همکاری اقتصادی و توسعهReproductive toxicity - سمیت تولید مثلRat - موش صحراییno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشدbody weight - وزن بدن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
(2R,4R)-Monatin salt [sodium/potassium 2R,4R-2-amino-4-carboxy-4-hydroxy-5-(3-indolyl) pentanoate] was fed at 5000, 15,000, or 35,000 ppm to Crl:CD(SD) rats over two generations. Reduced body weights were observed at all dose levels. Sustained effect on body weight gain at 35,000 ppm in the F0 and F1 parental animals was associated with lower feed efficiency, soft stool, and slightly lower numbers of implantation sites. Lower numbers of pups born and live litter size at 35,000 ppm were considered secondary to slightly lower numbers of former implantation sites in the dams. Spermatogenic endpoints, estrous cyclicity, reproductive performance, mean gestation length, and parturition were unaffected in the F0 and F1 generations. There were no effects on F1 and F2 generation postnatal survival. Reduced pre-weaning pup body weights at 35,000 ppm resulted in lower F1 and F2 body weights at study termination. Slight delays in pubertal landmarks in the F1 offspring were considered secondary to the reduced pup body weights. The no-observed-adverse-effect level (NOAEL) was 15,000 ppm for systemic, reproductive, and neonatal effects based on test article-related effects on body weight and food efficiency, slight decrease in maternal implantation sites and corresponding reduction in live litter size, and reductions in pre-weaning pup body weights at 35,000 ppm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 91, May 2016, Pages 167-180
Journal: Food and Chemical Toxicology - Volume 91, May 2016, Pages 167-180
نویسندگان
Christine M. Crincoli, Witty A. Brathwaite, Phillip L. Casterton, Marisa O. Rihner, Andrey I. Nikiforov, Eddie D. Sloter, Stephen B. Harris,