کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849810 | 1561764 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
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چکیده انگلیسی
Red oak (Quercus spp.) leaves are traditionally used as food in Mexico, and some of their infusions have potential anticarcinogenic and anti-inflammatory effects; however, these properties have not yet been scientifically tested. The aim of this work was to explore the anti-inflammatory activity in HT-29 cells and anticarcinogenic effect in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis of red oak infusions. Quercus infusions were prepared and administered as the sole source of drink to male Sprague-Dawley rats (1% w/v) for the entire 26-week experimental period. On week 4, rats received 8 subcutaneous injections of DMH (21âmg/kg body weight) once a week. The results showed that mean tumor (0.9â±â0.2 vs. 2.6â±â0.3) and multiplicity (1.2â±â0.1 vs. 2.0â±â0.23), and β-catenin protein level (2.2-fold) in adenocarcinomas were significantly lower in Quercus âsideroxyla-treated group compared with DMH group. By contrast, Quercus âdurifolia and Quercus âeduardii infusions had no protective effect. Additionally, the experiments in HT-29 cells confirmed that Q.âsideroxyla infusion effectively decreased the levels of the inflammatory markers COX-2 and IL-8 by modulating the expression of NF-κB. These results highlight some of the molecular mechanisms related to the chemopreventive effect of Q.âsideroxyla infusion and its potential value as a source of bioactive compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 80, June 2015, Pages 144-153
Journal: Food and Chemical Toxicology - Volume 80, June 2015, Pages 144-153
نویسندگان
Martha RocÃo Moreno-Jimenez, Fátima Trujillo-Esquivel, Marco A. Gallegos-Corona, Rosalia Reynoso-Camacho, Rubén Francisco González-Laredo, José Alberto Gallegos-Infante, Nuria Elizabeth Rocha-Guzmán, Minerva Ramos-Gomez,