کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5849811 1561764 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury
چکیده انگلیسی
Salvia lavandulifolia Vahl., known as “Spanish sage”, has potential value in dementia for its sedative, antioxidant, anti-inflammatory and anticholinesterase properties. This work aimed to evaluate the in vitro neuroprotective activity of S. lavandulifolia essential oils, obtained from plants at different phenological stages (vegetative and flowering phases) and plants grown at different densities, against H2O2-induced oxidative stress in PC12 cells. The effect on cell viability and morphology, lipid peroxidation, GSH/GSSG ratio, intracellular ROS levels, antioxidant enzymes (CAT, SOD, GR, GPx, HO-1) and apoptotic enzymes was investigated. Comparing with H2O2-treated PC12 cells, pretreatments with essential oil samples attenuated morphological changes and loss of cell viability, decreased MDA levels and intracellular ROS production and increased GSH/GSSG ratio. Moreover, Spanish sage increased antioxidant status as evidenced in an increase of antioxidant enzyme activity and protein expression and inhibited caspase-3 activity. Furthermore, our results suggest that S. lavandulifolia essential oils are able to activate Nrf2 transcription factor. Collectively, the sample of essential oil obtained with the highest densities of planting and at flowering phase exerted the major neuroprotective activity. Our findings demonstrate that S. lavandulifolia essential oils may have therapeutic value for the prevention and treatment of neurodegenerative diseases associated with oxidative stress-induced neuronal injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 80, June 2015, Pages 154-162
نویسندگان
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