کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849845 | 1561764 | 2015 | 5 صفحه PDF | دانلود رایگان |
- Hesperitin, a Citrus flavanone, induces melanin synthesis in human melanocytes.
- Hesperitin increases melanocyte tyrosinase activity.
- The melanogenic effect is observed in mouse melanoma cells and human melanocytes.
One of the major sources of flavonoids for humans are citrus fruits, hesperidin being the predominant flavonoid. Hesperetin (HSP), the aglycon of hesperidin, has been reported to provide health benefits such as antioxidant, anti-inflammatory and anticarcinogenic effects. However, the effect of HSP on skin pigmentation is not clear. Some authors have found that HSP induces melanogenesis in murine B16-F10 melanoma cells, which, if extrapolated to in vivo conditions, might protect skin against photodamage. Since the effect of HSP on normal melanocytes could be different to that observed on melanoma cells, the described effect of HSP on murine melanoma cells has been compared to the effect obtained using normal human melanocytes. HSP concentrations of 25 and 50âµM induced melanin synthesis and tyrosinase activity in human melanocytes in a concentration-dependent manner. Compared to control melanocytes, 25âµM HSP increased melanin production and tyrosinase activity 1.4-fold (pâ<â0.01) and 1.1-fold (pâ<â0.01), respectively, and the corresponding increases in the case of 50âµM HSP were 1.9-fold (pâ<â0.001) and 1.3-fold (pâ<â0.001). Therefore, HSP could be considered a valuable photoprotective substance if its capacity to increase melanin production in human melanocyte cultures could be reproduced on human skin.
Journal: Food and Chemical Toxicology - Volume 80, June 2015, Pages 80-84