کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849974 | 1561770 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aflatoxin exposure during the first 1000 days of life in rural South Asia assessed by aflatoxin B1-lysine albumin biomarkers
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
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چکیده انگلیسی
Aflatoxin B1 is a potent carcinogen, occurring from mold growth that contaminates staple grains in hot, humid environments. In this investigation, aflatoxin B1-lysine albumin biomarkers were measured by mass spectrometry in rural South Asian women, during the first and third trimester of pregnancy, and their children at birth and at two years of age. These subjects participated in randomized community trials of antenatal micronutrient supplementation in Sarlahi District, southern Nepal and Gaibandha District in northwestern Bangladesh. Findings from the Nepal samples demonstrated exposure to aflatoxin, with 94% detectable samples ranging from 0.45 to 2939.30âpg aflatoxin B1-lysine/mg albumin during pregnancy. In the Bangladesh samples the range was 1.56 to 63.22âpg aflatoxin B1-lysine/mg albumin in the first trimester, 3.37 to 72.8âpg aflatoxin B1-lysine/mg albumin in the third trimester, 4.62 to 76.69âpg aflatoxin B1-lysine/mg albumin at birth and 3.88 to 81.44âpg aflatoxin B1-lysine/mg albumin at age two years. Aflatoxin B1-lysine adducts in cord blood samples demonstrated that the fetus had the capacity to convert aflatoxin into toxicologically active compounds and the detection in the same 2-year-old children illustrates exposure over the first 1000 days of life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 74, December 2014, Pages 184-189
Journal: Food and Chemical Toxicology - Volume 74, December 2014, Pages 184-189
نویسندگان
John D. Groopman, Patricia A. Egner, Kerry J. Schulze, Lee S.-F. Wu, Rebecca Merrill, Sucheta Mehra, Abu A. Shamim, Hasmot Ali, Saijuddin Shaikh, Alison Gernand, Subarna K. Khatry, Steven C. LeClerq, Keith P. Jr, Parul Christian,