کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850249 | 1561775 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxicologic evaluation of Dichrostachys glomerata extract: Subchronic study in rats and genotoxicity tests
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کلمات کلیدی
GGTFDAGLDHNOAELMCVMCHOECDALTMNPCEPCEmicronucleated polychromatic erythrocytes - erythrocytes پلی کروماتیک میکرونAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییpolychromatic erythrocytes - اریتروسیت های چند رنگیSafety - ایمنیMean corpuscular volume - حجم متوسط مایعBUN - خوبFood and Drug Administration - سازمان غذا و داروOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیToxicity - سمی بودنmean corpuscular hemoglobin - متوسط هموگلوبین عضلانیDietary supplement - مکمل غذاییblood urea nitrogen - نیتروژن اوره خونno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشدGamma-glutamyl transferase - گاما گلوتامیل ترانسفرازglutamate dehydrogenase - گلوتامات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In western Cameroon, edible fruits and seeds from the plant Dichrostachys glomerata are commonly used as spices. Extract from the fruit pods has been reported as a good natural source of antioxidants and may provide health benefits. The objective of the present study was to investigate potential adverse effects, if any, of D. glomerata fruit pod extract (Dyglomeraâ¢) in a subchronic toxicity study and in genotoxicity studies. In the toxicity study, Sprague Dawley rats (20/sex/group) were gavaged with D. glomerata extract at dose levels of 0, 100, 1000 and 2500 mg/kg body weight (bw)/day for 90-days. Dyglomera⢠administration did not result in mortality or show treatmentrelated changes in clinical signs of toxicity, body weights, body weight gain or feed consumption. Similarly, no toxicologically significant treatment-related changes in hematological, clinical chemistry, urine analysis parameters, and organ weights were noted. Macroscopic and microscopic examinations did not reveal treatment-related abnormalities. Mutagenic and clastogenic potentials as evaluated by Ames assay, in vitro and in vivo chromosomal aberration test and in vivo micronucleus test did not reveal any genotoxicity of the extract. The results of subchronic toxicity study supports the no-observed-adverse-effect level (NOAEL) for D. glomerata extract as 2500 mg/kg bw/day, the highest dose tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 69, July 2014, Pages 120-131
Journal: Food and Chemical Toxicology - Volume 69, July 2014, Pages 120-131
نویسندگان
Shil C. Kothari, Prasad Shivarudraiah, Suresh Babu Venkataramaiah, Swapna Gavara, Shri Natrajan Arumugam, Madhu G. Soni,