کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850324 | 1561782 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Al on the splenic immune function and NE in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
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چکیده انگلیسی
Norepinephrine (NE) regulates the splenic immune function and it may be related to the effects of Aluminum (Al) on the splenic immune function. Here, the aim of this study was to further explore the effects of aluminum trichloride (AlCl3) on the splenic immune function and its relationship with NE. Forty male Wistar rats were orally exposed to AlCl3 (0, 64.18, 128.36 and 256.72Â mg/kg BW) through drinking water for 120Â days. The CD3+, CD4+, CD8+ T lymphocytes, the T and B lymphocytes proliferation rates and serum NE concentration were examined. The correlation analysis between splenic immune function and NE were done. The results showed that the CD3+, CD4+, CD8+ T lymphocytes and the T and B lymphocytes proliferation rates decreased and NE concentration increased in AlCl3-treated rats. NE was negatively correlated with proportions of CD3+, CD4+ T lymphocytes and T and B lymphocytes proliferation rates, but not correlated with CD8+ T lymphocytes. The results suggest that AlCl3 suppresses the splenic immune function and NE plays important role in this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 194-198
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 194-198
نویسندگان
Chongwei Hu, Jing Li, Yanzhu Zhu, Chongsheng Bai, Jihong Zhang, Shiliang Xia, Yanfei Li,