کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850551 | 1561777 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxic effects of silver nanoparticles and nanowires on erythrocyte rheology
ترجمه فارسی عنوان
اثرات سمی نانوذرات نقره و نانوسیمهای بر روی ریشه اریتروسیت
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کلمات کلیدی
نانوذرات نقره، نانوسیمهای نقره، خون، سم شناسی، هموراژولوژی، تغییر شکل پذیری،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Rapid developments in the food applications of silver nanomaterials (Ag-NMs) have resulted in concerns related to the risk of overexposure of human blood. We investigated the effect of size and aspect ratio of Ag-NMs on rheological characteristics of human erythrocytes, including hemolysis, deformability, aggregation, and morphological changes. Red blood cells (RBCs) were exposed to two different sizes of spherical particles (d â¼Â 30 nm or 100 nm) or nanowires (d â¼Â 40 nm, l-2 μm in length) at a range of concentrations and incubation times. The concentrations of Ag-NMs were carefully chosen to avoid any hemorheological alteration due to hemolysis. Rheological properties were measured using microfluidic-laser diffractometry and aggregometry. RBC deformability apparently decreased after treatment with a low concentration of Ag-NPs for a short exposure time. However, RBC aggregation was significantly altered after treatment with a low concentration of either Ag-NWs or large Ag-NPs compared to small Ag-NPs. Additional experiments with Ag ions confirmed that the observed rheological changes were mainly caused by the Ag-NMs rather than the Ag ions. These hemorheological findings provide a better understanding of the interaction between RBCs and Ag-NMs and will help in assessing the risk of nanomaterial toxicity in blood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 67, May 2014, Pages 80-86
Journal: Food and Chemical Toxicology - Volume 67, May 2014, Pages 80-86
نویسندگان
Min Jung Kim, Sehyun Shin,