کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850642 | 1561779 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells](/preview/png/5850642.png)
چکیده انگلیسی
Oxidative stress is one of the most critical factors implicated in many disorders of the gastrointestinal tract, such as inflammatory bowel diseases and colon cancer. Lunasin is a seed peptide known by its properties against cancer and cardiovascular diseases. The present study investigated the in vitro antioxidant activity of this peptide that demonstrated to be a potent scavenger of peroxyl and superoxide radicals. In addition, the protective role of lunasin on cell viability and antioxidant defenses of human Caco-2 cells challenged by hydrogen peroxide and tert-butylhydroperoxide was evaluated. This peptide remained partially intact during incubation time with cells, preventing of the oxidative damage induced by both chemical agents. The direct antioxidant action of lunasin (within the physiological range of concentrations) on enterocytes exposed to oxidizing species makes this peptide a promising agent to preserve the integrity of intestinal mucosa against oxidative damage related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 155-161
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 155-161
نویسندگان
MarÃa José GarcÃa-Nebot, Isidra Recio, Blanca Hernández-Ledesma,