کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850649 | 1561779 | 2014 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats
ترجمه فارسی عنوان
اثرات نفروپتیک عصاره میوه تاریخی بر روی مواجهه با دوز کلر اسیدهای اسید در موش بالغ
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
اسید دیکلوئوریک عصاره میوه تاریخی آب نشانگرهای کلیه، هیستوپاتولوژی، سیستم آنتیاکسیدان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
The aim of this study was to investigate the protective effects of aqueous date extract (ADE) on dichloroacetic acid (DCA)-induced nephrotoxicity. In vitro, total phenolic content estimated in the ADE were 417.71Â mg gallic acid equivalents/100Â g fresh weights (FW), while total flavonoid and tannins contents were 285.23 and 73.65Â mg catechin equivalents/100Â g FW, respectively. The ADE has strong scavenging activity. Ferulic, caffeic and p-coumaric acids are the major's compounds. Nephrotoxicity was induced in male Wistar rats by the administration of 0.5 and 2Â g/L DCA as drinking water. Some of these rats received also by gavage ADE (4Â mL/kg) before the administration of DCA. After two months of experiment, DCA administration caused elevated levels of renal MDA, significant depletion of GSH levels, altered the antioxidant enzyme activities and deteriorated the renal functions as assessed by the increased plasma urea, uric acid and creatinine levels compared to control rats. The treatment with the ADE significantly normalized the increased plasma levels of creatinine, urea and uric acid, reduced the elevated MDA levels, significantly normalized the antioxidant enzyme activities and GSH level and restored the altered kidney histology in rats treated with DCA. Therefore, it was speculated that ADE protects rats from kidney damage through its antioxidant capacity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 177-184
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 177-184
نویسندگان
Amira El Arem, Amira Thouri, Mouna Zekri, Emna Behija Saafi, Fatma Ghrairi, Abdelfattah Zakhama, Lotfi Achour,