Ninety-day dietary toxicity study of apple polyphenol extracts in Crl: CD (SD) rats

► Dietary Applephenon® in feed for 90 days induced no toxicological effects in rats. ► Acinar cell hypertrophy in saliva glands were physiological adaptive responses. ► The NOAEL of Applephenon® was 3214 mg/kg/day in males and 3621 mg/kg/day in females.