Can acetylcholinesterase activity be considered as a reliable biomarker for the assessment of cadmium-induced neurotoxicity?

► We comment on the recent work of Gonçalves et al. (2012). ► We discuss the variety of the current in vivo approaches to Cd neurotoxicity. ► We analyse the effects of Cd on brain acetylcholinesterase (AChE) activity. ► We present all relative in vivo and in vitro findings on the issue. ► We suggest the implementation of certain approaches for future studies.