Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

► The acetaminophen hepatotoxicity model is most popular for natural product testing. ► Pitfalls of the model make the interpretation of natural product studies difficult. ► Fundamental aspects of the model need to be considered for sound data interpretation. ► Goal is to enable researcher to select the appropriate experimental design and model. ► This yields clinically relevant and mechanistically valid data for natural products.