Verrucarin A enhances TRAIL-induced apoptosis via NF-κB-mediated Fas overexpression

► VA sensitizes HepG2 cells, but not mouse splenocytes, to TRAIL-induced apoptosis. ► VA/TRAIL induces apoptosis via NF-κB activation regardless of ER stress. ► Fas-induced cell death is triggered by VA/TRAIL treatment.