Zinc protection against aluminium induced altered lipid profile and membrane integrity

The aim of the present study was to investigate the effects of Zinc (Zn) supplementation on lipid profile and fluidity of cerebrum and cerebellum membranes of rats treated with aluminium (Al). Sprague dawley male rats were divided into four different treatment groups viz: Control, aluminium treated, zinc treated and aluminium + zinc treated. Aluminium (AlCl3) was administered orally at a dose of 100 mg/kg b.wt./day (dissolved in drinking water). Zinc as zinc sulphate was supplemented to rats at a dose of 227 mg/l in drinking water. A significant decrease in the levels of total lipids, glycolipids, phospholipids, cholesterol and gangliosides contents were observed in both the cerebrum and cerebellum following Al exposure, which were found to be significantly increased following Zn supplementation. On the contrary, Al treatment caused a significant increase in the formation of conjugated dienes, which were observed to be reduced on Zn co-treatment. Further, Al treatment significantly elevated the fluorescence polarization, anisotropy and order parameter, which however were normalized upon Zn co-administration. Hence, the present study depicts the potential of Zn in moderating the changes caused by Al on membrane composition and fluidity in rat brain.

► Present study revealed role of zinc in aluminium induced neurotoxicity. ► Al caused alterations in membrane lipids composition which were restored on Zn treatment. ► Al induced altered membrane fluidity were improved on Zn supplementation. ► Zn protects against Al induced disturbed membrane integrity.