Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells

► Eugenol specifically blocked DNA oxidation and lipid peroxidation induced by hydroxyl radical. ► Eugenol inhibited MMP-9 activities in PMA-stimulated HT1080 cells. ► Eugenol exerts inhibitory effects on MMP-9 via inactivation of ERK.