Dendritic cell activation by polysaccharide isolated from Angelica dahurica

► ADP strongly activates dendritic cells to produce cytokines, decrease antigen uptake, and enhance allogenic T cell stimulation. ► ADP activates dendritic cells via binding to membrane receptor TLR4. ► ADP activates MAPKs and NF-κB signalings downstream from TLR4 in dendritic cells.