کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5851662 1561789 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benchmark dose for estimation of cadmium reference level for osteoporosis in a Chinese female population
ترجمه فارسی عنوان
دوز استاندارد برای برآورد سطح مرجع کادمیم برای پوکی استخوان در یک زن چینی
کلمات کلیدی
دوز معیار، کادمیوم، پوکی استخوان، زنان،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی
In this study, the reference level of cadmium in urine and blood related with bone damage was assessed using benchmark dose in a Chinese female population. Total of 338 women was recruited, and urine and blood samples were collected from each individual for determination of cadmium in urine (UCd) and blood (BCd). Bone mineral density was measured by dual energy X-ray absorptiometry. BMD and BMDL were calculated corresponding to additional risk of 5% and 10%. With benchmark response (BMR) of 5%/10%, the BMD of BCd, UCd related with osteoporosis was 1.88 μg/L/3.23 μg/L and 5.30 μg/g crea/9.06 μg/g crea, and the BMDL-05 was 1.39 μg/L/2.38 μg/L and 3.78 μg/g crea/6.36 μg/g crea; the BMD of BCd, UCd related with low bone mass was 0.95 μg/L/3.12 μg/L and 3.12 μg/g crea/5.87 μg/g crea, and the BMDL-05 was 0.72 μg/L/1.35 μg/L and 2.14 μg/g crea/3.99 μg/g crea. The BMD of UCd in people over 60 years old was much lower than that of people less than 60 years old. BMD value was related with ages and effects biomarkers. Our data showed that BMD of UCd associated with osteoporosis was lower than that previously estimated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 55, May 2013, Pages 592-595
نویسندگان
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