کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5851786 | 1561786 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunostimulatory and antiangiogenic activities of low molecular weight hyaluronic acid
ترجمه فارسی عنوان
فعالیت های ایمنی و ضد انعقادی اسید هیالورونیک کم مولکولی
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کلمات کلیدی
اسید هیالورونیک، وزن مولکولی کم اسید هیالورونیک، فعالیت ایمنی فعالیت ضد انعقادی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
The immunostimulatory activities of two low molecular weight hyaluronic acids (LMWHA-1 and LMWHA-2 with MW of 1.45Â ÃÂ 105 and 4.52Â ÃÂ 104Â Da, respectively) and HA (MW, 1.05Â ÃÂ 106Â Da) were evaluated by using in vitro cell models and in vivo animal models, and their effects on angiogenesis were measured in vivo by using the chick embryo chorioallantoic membrane (CAM) assay. The results demonstrated that LMWHA-1, LMWHA-2 and HA could promote the splenocyte proliferation, increase the activity of acid phosphatase in peritoneal macrophages and strengthen peritoneal macrophages to devour neutral red in vitro in a dose-dependent manner. Furthermore, LMWHA-1 and LMWHA-2 exhibited much stronger immunostimulatory activity than HA. For assay in vivo, LMWHA-1 and LMWHA-2 significantly increased the indices of spleen and thymus, the activity of lysozyme in serum and the swelling rate of earlap in delayed-type hypersensitivity in a dose-dependent manner. In the CAM model, the results showed that LMWHA-1, LMWHA-2 and HA suppressed angiogenesis in chicken embryos. Moreover, LMWHA-1 exhibited higher antiangiogenesis activity than LMWHA-2 and HA. All these results suggested that LMWHA might be a potential natural immunomodulator and a potential candidate compound for antiangiogenic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 401-407
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 401-407
نویسندگان
Chunlin Ke, Di Wang, Yi Sun, Deliang Qiao, Hong Ye, Xiaoxiong Zeng,