A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

► Antioxidants and prooxidants have been intensively studied over the past few decades. ► Recently, controversy has intensified in this area due to conflicting results. ► Natural and synthetic antioxidants both have advantages and disadvantages. ► Many different methods are used to screen matrixes or to find specific antioxidants. ► Due to some limitations, new methodologies are being prepared.