Multifunctional targets of dietary polyphenols in disease: A case for the chemokine network and energy metabolism

► Inflammation and metabolism are closely interrelated in the pathophysiology of non-communicable diseases. ► Polyphenols may be useful in treating and preventing these conditions. ► Cellular stress represents a link between the chemokine network and energy metabolism. ► Bioavailability, transformation and toxicity of polyphenols are unresolved issues.